Atypical protein kinase C in glucose metabolism
XJ Liu, AB He, YS Chang, FD Fang - Cellular signalling, 2006 - Elsevier
XJ Liu, AB He, YS Chang, FD Fang
Cellular signalling, 2006•ElsevierType 2 diabetes mellitus is a multigenic disease with evident genetic predisposition, and
complex pathogenesis in which environmental and genetic factors interact. The disorder of
body utilization glucose is a crucial reason for causing diabetes. Atypical PKCs, belonging to
Ser/Thr protein kinase, have many important biological functions in vivo, and may be
involved in the pathogenesis of diabetes mellitus. APKCs participate in glucose metabolism
by regulating glucose transport and absorption, glycogen synthesis, and insulin secretion …
complex pathogenesis in which environmental and genetic factors interact. The disorder of
body utilization glucose is a crucial reason for causing diabetes. Atypical PKCs, belonging to
Ser/Thr protein kinase, have many important biological functions in vivo, and may be
involved in the pathogenesis of diabetes mellitus. APKCs participate in glucose metabolism
by regulating glucose transport and absorption, glycogen synthesis, and insulin secretion …
Type 2 diabetes mellitus is a multigenic disease with evident genetic predisposition, and complex pathogenesis in which environmental and genetic factors interact. The disorder of body utilization glucose is a crucial reason for causing diabetes. Atypical PKCs, belonging to Ser/Thr protein kinase, have many important biological functions in vivo, and may be involved in the pathogenesis of diabetes mellitus. APKCs participate in glucose metabolism by regulating glucose transport and absorption, glycogen synthesis, and insulin secretion. The exact mechanism by which aPKCs participate in glucose metabolism remains unclear. So far, the clarification of which will be helpful for the prevention and cure of type 2 diabetes.
Elsevier