Background The incidence of eosinophilic esophagitis (EoE) is greater in male than female
subjects, and the underlying molecular basis for this sex bias remains unclear. Objective We
sought to delineate the contribution of the sex hormone estrogen to the EoE phenotype and
esophageal epithelial barrier function and remodeling. Methods We performed demographic
and incidence analyses of EoE in male and female subjects from a single-center pediatric
cohort. Estrogen-responsive gene expression analyses and estrogen receptor (ESR) …