Regulation of osteoclast differentiation and function by interleukin‐1
I Nakamura, E Jimi - Vitamins & Hormones, 2006 - Elsevier
Interleukin‐1 (IL‐1) is a multifunctional cytokine that regulates various cellular and tissue
functions. Among tissues, bone is the most sensitive to IL‐1. IL‐1 is a potent cytokine for
bone resorption and participates in the multiple steps of osteoclast recruitment, such as
differentiation, multinucleation, activation, and survival. On the other hand, considerable
evidence has been accumulated over the past 10 years to indicate that this cytokine plays
key roles in pathological bone destruction in a variety of human diseases, including …
functions. Among tissues, bone is the most sensitive to IL‐1. IL‐1 is a potent cytokine for
bone resorption and participates in the multiple steps of osteoclast recruitment, such as
differentiation, multinucleation, activation, and survival. On the other hand, considerable
evidence has been accumulated over the past 10 years to indicate that this cytokine plays
key roles in pathological bone destruction in a variety of human diseases, including …