4-PBA prevents pressure overload-induced myocardial hypertrophy and interstitial fibrosis by attenuating endoplasmic reticulum stress
Our previous study indicated that attenuation of endoplasmic reticulum (ER) stress by
administration of 4-phenylbutyric acid (4-PBA) could prevent cardiac rupture and remodeling
in a mouse model of myocardial infarction (MI). However, whether 4-PBA is protective in
hypertrophic heart disease is unclear. Thus, we tested the therapeutic effect of 4-PBA on
pressure-overload induced myocardial hypertrophy. Transverse aortic constriction (TAC)
was used to create myocardial hypertrophy in C57BL/6 male mice for 4 weeks. Immediately …
administration of 4-phenylbutyric acid (4-PBA) could prevent cardiac rupture and remodeling
in a mouse model of myocardial infarction (MI). However, whether 4-PBA is protective in
hypertrophic heart disease is unclear. Thus, we tested the therapeutic effect of 4-PBA on
pressure-overload induced myocardial hypertrophy. Transverse aortic constriction (TAC)
was used to create myocardial hypertrophy in C57BL/6 male mice for 4 weeks. Immediately …