Targeting the unfolded protein response in heart diseases
M Liu, SC Dudley Jr - Expert opinion on therapeutic targets, 2014 - Taylor & Francis
Expert opinion on therapeutic targets, 2014•Taylor & Francis
In neurological disease and diabetes, the unfolded protein response (UPR) has been
investigated for years, while its function in heart disease is less well understood. All three
branches of the UPR are involved in ischaemia/reperfusion and can either protect or impair
heart function. Recently, UPR has been found to play a role in arrhythmogenesis during
human heart failure, and blocking UPR has an antiarrhythmic effect. This review will discuss
the rationale for and challenges to targeting UPR in heart disease.
investigated for years, while its function in heart disease is less well understood. All three
branches of the UPR are involved in ischaemia/reperfusion and can either protect or impair
heart function. Recently, UPR has been found to play a role in arrhythmogenesis during
human heart failure, and blocking UPR has an antiarrhythmic effect. This review will discuss
the rationale for and challenges to targeting UPR in heart disease.
In neurological disease and diabetes, the unfolded protein response (UPR) has been investigated for years, while its function in heart disease is less well understood. All three branches of the UPR are involved in ischaemia/reperfusion and can either protect or impair heart function. Recently, UPR has been found to play a role in arrhythmogenesis during human heart failure, and blocking UPR has an antiarrhythmic effect. This review will discuss the rationale for and challenges to targeting UPR in heart disease.
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