Attenuation of ER stress prevents post-infarction-induced cardiac rupture and remodeling by modulating both cardiac apoptosis and fibrosis
Endoplasmic reticulum (ER) stress is implicated in the pathophysiology of various
cardiovascular diseases, but the role of ER stress in cardiac rupture and/or remodeling after
myocardial infarction (MI) is still unclear. Here we investigated whether ER stress plays a
major role for these processes in mice. We ligated the left coronary artery (LCA) without
reperfusion in mice and administered either NaCl or 4-phenylbutyric acid (4-PBA, 20
mg/kg/d) intraperitoneally for 4 weeks. Cardiac rupture rates during the first week of MI were …
cardiovascular diseases, but the role of ER stress in cardiac rupture and/or remodeling after
myocardial infarction (MI) is still unclear. Here we investigated whether ER stress plays a
major role for these processes in mice. We ligated the left coronary artery (LCA) without
reperfusion in mice and administered either NaCl or 4-phenylbutyric acid (4-PBA, 20
mg/kg/d) intraperitoneally for 4 weeks. Cardiac rupture rates during the first week of MI were …