[HTML][HTML] Chemical chaperone 4-phenylbutyric acid reduces cardiac ischemia/reperfusion injury by alleviating endoplasmic reticulum stress and oxidative stress

L Jian, Y Lu, S Lu, C Lu - Medical science monitor: international …, 2016 - ncbi.nlm.nih.gov
L Jian, Y Lu, S Lu, C Lu
Medical science monitor: international medical journal of experimental …, 2016ncbi.nlm.nih.gov
Background Cardiovascular diseases are the leading cause of death in many countries and
myocardial ischemia-reperfusion (I/R) injury is the cause of many serious heart diseases.
Recent reports suggested that endoplasmic reticulum (ER) stress is associated with the
progress of ischemia/reperfusion (I/R) injury. In a previous study, we illustrated that 4-
phenylbutyric acid (4-PBA) reduces I/R-induced cell death in vitro through inhibiting the ER
stress-initiated cell apoptosis. In the present study we investigated whether 4-PBA improves …
Abstract
Background
Cardiovascular diseases are the leading cause of death in many countries and myocardial ischemia-reperfusion (I/R) injury is the cause of many serious heart diseases. Recent reports suggested that endoplasmic reticulum (ER) stress is associated with the progress of ischemia/reperfusion (I/R) injury. In a previous study, we illustrated that 4-phenylbutyric acid (4-PBA) reduces I/R-induced cell death in vitro through inhibiting the ER stress-initiated cell apoptosis. In the present study we investigated whether 4-PBA improves heart function in isolated rat hearts subjected to I/R and elucidated the potential mechanisms involved in 4-PBA-induced cardioprotective effects.
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