[HTML][HTML] Sarco/endoplasmic reticulum calcium ATPase-2 expression is regulated by ATF6 during the endoplasmic reticulum stress response: intracellular signaling of …
DJ Thuerauf, H Hoover, J Meller, J Hernandez… - Journal of Biological …, 2001 - ASBMB
The recently described transcription factor, ATF6, mediates the expression of proteins that
compensate for potentially stressful changes in the endoplasmic reticulum (ER), such as
reduced ER calcium. In cardiac myocytes the maintenance of optimal calcium levels in the
sarcoplasmic reticulum (SR), a specialized form of the ER, is required for proper contractility.
The present study investigated the hypothesis that ATF6 serves as a regulator of the
expression of sarco/endoplasmic reticulum calcium ATPase-2 (SERCA2), a protein that …
compensate for potentially stressful changes in the endoplasmic reticulum (ER), such as
reduced ER calcium. In cardiac myocytes the maintenance of optimal calcium levels in the
sarcoplasmic reticulum (SR), a specialized form of the ER, is required for proper contractility.
The present study investigated the hypothesis that ATF6 serves as a regulator of the
expression of sarco/endoplasmic reticulum calcium ATPase-2 (SERCA2), a protein that …