[HTML][HTML] Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis

A Visekruna, T Linnerz, V Martinic, N Vachharajani… - Mucosal …, 2015 - Elsevier
Genetic and environmental factors, including the commensal microbiota, have a crucial role
in the development of inflammatory bowel disease. Aberrant activation of the transcription
factor NF-κB is associated with chronic intestinal inflammation in mice and humans.
Recently, an emerging family of innate lymphoid cells (ILCs) has been identified at mucosal
sites contributing to the maintenance of gut homeostasis and intestinal immunopathology.
Here, we show that the NF-κB protein c-Rel regulates the inflammatory potential of colonic …