H2S: a novel gasotransmitter that signals by sulfhydration
BD Paul, SH Snyder - Trends in biochemical sciences, 2015 - cell.com
BD Paul, SH Snyder
Trends in biochemical sciences, 2015•cell.comHydrogen sulfide (H 2 S) is a member of the growing family of gasotransmitters. Once
regarded as a noxious molecule predominantly present in the atmosphere, H 2 S is now
known to be synthesized endogenously in mammals. H 2 S participates in a myriad of
physiological processes ranging from regulation of blood pressure to neuroprotection. Its
chemical nature precludes H 2 S from being stored in vesicles and acting on receptor
proteins in the fashion of other chemical messengers. Thus, novel cellular mechanisms have …
regarded as a noxious molecule predominantly present in the atmosphere, H 2 S is now
known to be synthesized endogenously in mammals. H 2 S participates in a myriad of
physiological processes ranging from regulation of blood pressure to neuroprotection. Its
chemical nature precludes H 2 S from being stored in vesicles and acting on receptor
proteins in the fashion of other chemical messengers. Thus, novel cellular mechanisms have …
Hydrogen sulfide (H2S) is a member of the growing family of gasotransmitters. Once regarded as a noxious molecule predominantly present in the atmosphere, H2S is now known to be synthesized endogenously in mammals. H2S participates in a myriad of physiological processes ranging from regulation of blood pressure to neuroprotection. Its chemical nature precludes H2S from being stored in vesicles and acting on receptor proteins in the fashion of other chemical messengers. Thus, novel cellular mechanisms have evolved to mediate its effects. This review focuses on sulfhydration (or persulfidation), which appears to be the principal post-translational modification elicited by H2S.
cell.com