[HTML][HTML] Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic β cells
V Dominguez, C Raimondi, S Somanath… - Journal of Biological …, 2011 - ASBMB
Phosphoinositide 3-kinases (PI3Ks) are critical regulators of pancreatic β cell mass and
survival, whereas their involvement in insulin secretion is more controversial. Furthermore,
of the different PI3Ks, the class II isoforms were detected in β cells, although their role is still
not well understood. Here we show that down-regulation of the class II PI3K isoform PI3K-
C2α specifically impairs insulin granule exocytosis in rat insulinoma cells without affecting
insulin content, the number of insulin granules at the plasma membrane, or the expression …
survival, whereas their involvement in insulin secretion is more controversial. Furthermore,
of the different PI3Ks, the class II isoforms were detected in β cells, although their role is still
not well understood. Here we show that down-regulation of the class II PI3K isoform PI3K-
C2α specifically impairs insulin granule exocytosis in rat insulinoma cells without affecting
insulin content, the number of insulin granules at the plasma membrane, or the expression …