Delayed administration of human inter-α inhibitor proteins reduces mortality in sepsis
R Wu, X Cui, YP Lim, K Bendelja, M Zhou… - Critical care …, 2004 - journals.lww.com
Objective: We have recently shown that administration of human inter-α inhibitor proteins
(IαIp) very early after the onset of sepsis maintains cardiovascular stability and reduced
mortality. However, it remains unknown whether injection of IαIp at later time points of sepsis
has any beneficial effects. We therefore hypothesized that IαIp and its active component
bikunin are reduced in sepsis and that the delayed administration of IαIp also improves
survival rate. Design: Prospective, controlled, and randomized animal study. Setting: A …
(IαIp) very early after the onset of sepsis maintains cardiovascular stability and reduced
mortality. However, it remains unknown whether injection of IαIp at later time points of sepsis
has any beneficial effects. We therefore hypothesized that IαIp and its active component
bikunin are reduced in sepsis and that the delayed administration of IαIp also improves
survival rate. Design: Prospective, controlled, and randomized animal study. Setting: A …