[HTML][HTML] Plasma levels of inter-α inhibitor proteins in children with acute dengue virus infection
P Koraka, YP Lim, MD Shin, TE Setiati, ATA Mairuhu… - PLoS …, 2010 - journals.plos.org
P Koraka, YP Lim, MD Shin, TE Setiati, ATA Mairuhu, ECM van Gorp, A Soemantri…
PLoS One, 2010•journals.plos.orgBackground Inter-α inhibitor proteins (IaIp) belong to a family of protease inhibitors that are
involved in the haemostatic and the vascular system. Dengue viruses (DENV) infections are
characterized by coagulopathy and increased vascular permeability. In this study we
measured the concentration of IaIp during DENV infections and evaluated its potential as a
biomarker. Methods and Findings Concentrations of IaIp were measured in patients with
acute DENV infections using a quantitative, competitive enzyme linked immunoassay …
involved in the haemostatic and the vascular system. Dengue viruses (DENV) infections are
characterized by coagulopathy and increased vascular permeability. In this study we
measured the concentration of IaIp during DENV infections and evaluated its potential as a
biomarker. Methods and Findings Concentrations of IaIp were measured in patients with
acute DENV infections using a quantitative, competitive enzyme linked immunoassay …
Background
Inter-α inhibitor proteins (IaIp) belong to a family of protease inhibitors that are involved in the haemostatic and the vascular system. Dengue viruses (DENV) infections are characterized by coagulopathy and increased vascular permeability. In this study we measured the concentration of IaIp during DENV infections and evaluated its potential as a biomarker.
Methods and Findings
Concentrations of IaIp were measured in patients with acute DENV infections using a quantitative, competitive enzyme linked immunoassay. Concentrations of IaIp measured in pediatric patients suffering from severe DENV infections were significantly lower than in healthy controls.
Conclusions
This is the first report to demonstrate changes in concentration of IaIp during viral infections. The data also highlight the potential of IaIp as a biological marker for severity of DENV infections.
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