[HTML][HTML] ATF6 mediates a pro-inflammatory synergy between ER stress and TLR activation in the pathogenesis of liver ischemia-reperfusion injury
J Rao, S Yue, Y Fu, J Zhu, X Wang, RW Busuttil… - American Journal of …, 2014 - Elsevier
Although the roles of the metabolic stress in organ ischemia-reperfusion injury (IRI) have
been well recognized, the question of whether and how these stress responses regulate
innate immune activation against IR remains unclear. In a murine liver partial warm ischemia
mode, we showed that prolonged ischemia triggered endoplasmic reticulum (ER) stress
response, particularly, the activating transcription factor 6 (ATF6) branch, in liver Kupffer
cells (KCs) and altered their responsiveness against Toll-like receptor (TLR) stimulation …
been well recognized, the question of whether and how these stress responses regulate
innate immune activation against IR remains unclear. In a murine liver partial warm ischemia
mode, we showed that prolonged ischemia triggered endoplasmic reticulum (ER) stress
response, particularly, the activating transcription factor 6 (ATF6) branch, in liver Kupffer
cells (KCs) and altered their responsiveness against Toll-like receptor (TLR) stimulation …