[HTML][HTML] Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186
K Fujimoto, M Kinoshita, H Tanaka, D Okuzaki… - Mucosal …, 2017 - Elsevier
Genome-wide association studies and subsequent deep sequencing analysis have
identified susceptible loci for inflammatory bowel diseases (IBDs) including ulcerative colitis
(UC). A gene encoding RING finger protein 186 (RNF186) is located within UC-susceptible
loci. However, it is unclear whether RNF186 is involved in IBD pathogenesis. Here, we show
that RNF186 controls protein homeostasis in colonic epithelia and regulates intestinal
inflammation. RNF186, which was highly expressed in colonic epithelia, acted as an E3 …
identified susceptible loci for inflammatory bowel diseases (IBDs) including ulcerative colitis
(UC). A gene encoding RING finger protein 186 (RNF186) is located within UC-susceptible
loci. However, it is unclear whether RNF186 is involved in IBD pathogenesis. Here, we show
that RNF186 controls protein homeostasis in colonic epithelia and regulates intestinal
inflammation. RNF186, which was highly expressed in colonic epithelia, acted as an E3 …