[HTML][HTML] The 39-kDa Receptor-associated Protein Modulates Lipoprotein Catabolism by Binding to LDL Receptors (∗)
JD Medh, GL Fry, SL Bowen, MW Pladet… - Journal of Biological …, 1995 - ASBMB
The 39-kDa receptor-associated protein (RAP) is co-synthesized and co-purifies with the low
density lipoprotein receptor-related protein (LRP)/α 2-macroglobulin receptor and is thought
to modulate ligand binding to LRP. In addition to binding LRP, RAP binds two other
members of the low density lipoprotein (LDL) receptor family, gp330 and very low density
lipoprotein (VLDL) receptors. Here, we show that RAP binds to LDL receptors as well. In
normal human foreskin fibroblasts, RAP inhibited LDL receptor-mediated binding and …
density lipoprotein receptor-related protein (LRP)/α 2-macroglobulin receptor and is thought
to modulate ligand binding to LRP. In addition to binding LRP, RAP binds two other
members of the low density lipoprotein (LDL) receptor family, gp330 and very low density
lipoprotein (VLDL) receptors. Here, we show that RAP binds to LDL receptors as well. In
normal human foreskin fibroblasts, RAP inhibited LDL receptor-mediated binding and …