[HTML][HTML] Regulation of the composition of the extracellular matrix by low density lipoprotein receptor-related protein-1: activities based on regulation of mRNA …

A Gaultier, AM Salicioni, S Arandjelovic… - Journal of biological …, 2006 - ASBMB
Low density lipoprotein receptor-related protein-1 (LRP-1) is a catabolic receptor for
extracellular matrix (ECM) structural proteins and for proteins that bind to ECM. LRP-1 also
is implicated in integrin maturation. In this study, we applied a proteomics strategy to identify
novel proteins involved in ECM modeling that are regulated by LRP-1. We show that LRP-1
deficiency in murine embryonic fibroblasts (MEFs) is associated with increased levels of type
III collagen and pigment epithelium-derived factor, which accumulate in the substratum …