Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses
M Hashiguchi, H Kobori, P Ritprajak… - Proceedings of the …, 2008 - National Acad Sciences
Proceedings of the National Academy of Sciences, 2008•National Acad Sciences
The B7 family member B7-H3 (CD276) plays important roles in immune responses.
However, the function of B7-H3 remains controversial. We found that murine B7-H3
specifically bound to Triggering receptor expressed on myeloid cells (TREM)-like transcript 2
(TLT-2, TREML2). TLT-2 was expressed on CD8+ T cells constitutively and on activated
CD4+ T cells. Stimulation with B7-H3 transfectants preferentially up-regulated the
proliferation and IFN-γ production of CD8+ T cells. Transduction of TLT-2 into T cells …
However, the function of B7-H3 remains controversial. We found that murine B7-H3
specifically bound to Triggering receptor expressed on myeloid cells (TREM)-like transcript 2
(TLT-2, TREML2). TLT-2 was expressed on CD8+ T cells constitutively and on activated
CD4+ T cells. Stimulation with B7-H3 transfectants preferentially up-regulated the
proliferation and IFN-γ production of CD8+ T cells. Transduction of TLT-2 into T cells …
The B7 family member B7-H3 (CD276) plays important roles in immune responses. However, the function of B7-H3 remains controversial. We found that murine B7-H3 specifically bound to Triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2, TREML2). TLT-2 was expressed on CD8+ T cells constitutively and on activated CD4+ T cells. Stimulation with B7-H3 transfectants preferentially up-regulated the proliferation and IFN-γ production of CD8+ T cells. Transduction of TLT-2 into T cells resulted in enhanced IL-2 and IFN-γ production via interactions with B7-H3. Blockade of the B7-H3:TLT-2 pathway with a mAb against B7-H3 or TLT-2 efficiently inhibited contact hypersensitivity responses. Our results demonstrate a direct interaction between B7-H3 and TLT-2 that preferentially enhances CD8+ T cell activation.
National Acad Sciences