[HTML][HTML] The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum
JJ Hill, MV Davies, AA Pearson, JH Wang… - Journal of Biological …, 2002 - ASBMB
Myostatin, also known as growth and differentiation factor 8, is a member of the transforming
growth factor β superfamily that negatively regulates skeletal muscle mass (1). Recent
experiments have shown that myostatin activity is detected in serum by a reporter gene
assay only after activation by acid, suggesting that native myostatin circulates as a latent
complex (2). We have used a monoclonal myostatin antibody, JA16, to isolate the native
myostatin complex from normal mouse and human serum. Analysis by mass spectrometry …
growth factor β superfamily that negatively regulates skeletal muscle mass (1). Recent
experiments have shown that myostatin activity is detected in serum by a reporter gene
assay only after activation by acid, suggesting that native myostatin circulates as a latent
complex (2). We have used a monoclonal myostatin antibody, JA16, to isolate the native
myostatin complex from normal mouse and human serum. Analysis by mass spectrometry …