Role for the endoplasmic reticulum stress sensor IRE1α in liver regenerative responses
Y Liu, M Shao, Y Wu, C Yan, S Jiang, J Liu, J Dai… - Journal of …, 2015 - Elsevier
Background & Aims As the main detoxifying organ of the body, the liver possesses a
remarkable ability to regenerate after toxic injury, tissue resection or viral infection. A
growing number of cellular signaling pathways have been implicated in orchestrating the
process of liver regeneration. Here we investigated the role of inositol-requiring enzyme-1α
(IRE1α), a key signal transducer of the unfolded protein response (UPR), in liver
regeneration. Methods Using mice with hepatocyte-specific deletion of IRE1α, we examined …
remarkable ability to regenerate after toxic injury, tissue resection or viral infection. A
growing number of cellular signaling pathways have been implicated in orchestrating the
process of liver regeneration. Here we investigated the role of inositol-requiring enzyme-1α
(IRE1α), a key signal transducer of the unfolded protein response (UPR), in liver
regeneration. Methods Using mice with hepatocyte-specific deletion of IRE1α, we examined …