FGF2-induced STAT3 activation regulates pathologic neovascularization
Z Dong, A Santeford, N Ban, TJ Lee, C Smith… - Experimental eye …, 2019 - Elsevier
Cell-autonomous endothelial cell (EC) fibroblast growth factor receptor (FGFR) signaling
through FGFR1/2 is essential for injury-induced wound vascularization and pathologic
neovascularization as in blinding eye diseases such as age-related macular degeneration.
Which FGF ligand (s) is critical in regulating angiogenesis is unknown. Utilizing ex vivo
models of choroidal endothelial sprouting and in vivo models of choroidal
neovascularization (CNV), we demonstrate here that only FGF2 is the essential ligand …
through FGFR1/2 is essential for injury-induced wound vascularization and pathologic
neovascularization as in blinding eye diseases such as age-related macular degeneration.
Which FGF ligand (s) is critical in regulating angiogenesis is unknown. Utilizing ex vivo
models of choroidal endothelial sprouting and in vivo models of choroidal
neovascularization (CNV), we demonstrate here that only FGF2 is the essential ligand …