The roles of HLH transcription factors in epithelial mesenchymal transition and multiple molecular mechanisms
Y Teng, X Li - Clinical & experimental metastasis, 2014 - Springer
Y Teng, X Li
Clinical & experimental metastasis, 2014•SpringerEpithelial-to-mesenchymal transition (EMT) is presently recognized as an important event
and the initiating stage for tumor invasion and metastasis. Several EMT inducers have been
identified, among which the big family of helix–loop–helix (HLH) transcription factors are
rising as a novel and promising family of proteins in EMT mediation, such as Twist1, Twist2,
E47, and HIFs, etc. Due to the variety and complexities of HLH members, the pathways and
mechanisms they employ to promote EMT are also complex and characteristic. In this …
and the initiating stage for tumor invasion and metastasis. Several EMT inducers have been
identified, among which the big family of helix–loop–helix (HLH) transcription factors are
rising as a novel and promising family of proteins in EMT mediation, such as Twist1, Twist2,
E47, and HIFs, etc. Due to the variety and complexities of HLH members, the pathways and
mechanisms they employ to promote EMT are also complex and characteristic. In this …
Abstract
Epithelial-to-mesenchymal transition (EMT) is presently recognized as an important event and the initiating stage for tumor invasion and metastasis. Several EMT inducers have been identified, among which the big family of helix–loop–helix (HLH) transcription factors are rising as a novel and promising family of proteins in EMT mediation, such as Twist1, Twist2, E47, and HIFs, etc. Due to the variety and complexities of HLH members, the pathways and mechanisms they employ to promote EMT are also complex and characteristic. In this review, we will discuss the roles of various HLH proteins in the regulation and sustenance of the EMT and multiple cellular mechanisms, attempting to provide a novel and broadened view towards the link between HLH proteins and EMT.
Springer