Endothelial-to-mesenchymal transition: cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions

L Pérez, N Muñoz-Durango, CA Riedel… - Cytokine & growth factor …, 2017 - Elsevier
During the last decade, the endothelial-to-mesenchymal transition (EndMT) process has
attracted considerable attention due to associations with the onset of certain diseases, such
as organ fibrosis and cancer. Several studies have assessed the mechanisms and signaling
pathways that regulate endothelial fibrosis in the context of human pathologies. A number of
inflammatory mediators, including pro-inflammatory cytokines, growth factors, oxidative
stress, and toxins, induce the conversion of endothelial cells into mesenchymal fibroblast …