Context Chondroitin sulfate proteoglycans (CSPGs), a main component of the brain
extracellular matrix, regulate developmental and adult neural functions that are highly
relevant to the pathogenesis of schizophrenia. Such functions, together with marked
expression of CSPGs in astrocytes within the normal human amygdala and evidence of a
disruption of astrocytic functions in this disease, point to involvement of CSPG-glial
interactions in schizophrenia. Hypothesis Chondroitin sulfate proteoglycan–related …