MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions
N Kishi, JD Macklis - Molecular and Cellular Neuroscience, 2004 - Elsevier
Rett syndrome is a neurodevelopmental disorder and one of the causes of mental
retardation and autistic behavior in girls, as well as in a small group of boys. It was recently
discovered that mutation of the methyl-CpG-binding protein 2 (MECP2) gene encoding a
transcriptional repressor on the X chromosome causes Rett syndrome. Although it is evident
that phenotypes of MECP2 mutant mice that resemble those of Rett syndrome are
attributable to lack of the MECP2 gene in the central nervous system (CNS), there is little …
retardation and autistic behavior in girls, as well as in a small group of boys. It was recently
discovered that mutation of the methyl-CpG-binding protein 2 (MECP2) gene encoding a
transcriptional repressor on the X chromosome causes Rett syndrome. Although it is evident
that phenotypes of MECP2 mutant mice that resemble those of Rett syndrome are
attributable to lack of the MECP2 gene in the central nervous system (CNS), there is little …