The pathologic physiology of chronic Bright's disease: an exposition of the “intact nephron hypothesis”
NS Bricker, PAF Morrin, SW Kime Jr - The American journal of medicine, 1960 - Elsevier
Clinical and experimental data relating to the functional capacity of the surviving nephrons of
the chronically diseased kidney for the most part support the thesis that these nephrons
retain their essential functional integrity regardless of the nature of the underlying form of
chronic Bright's disease. There are instances in which specific alterations of function
correlate with pathologic involvement of a particular site of the nephron but these appear to
represent the exceptions, and in general the more advanced the disease becomes, the less …
the chronically diseased kidney for the most part support the thesis that these nephrons
retain their essential functional integrity regardless of the nature of the underlying form of
chronic Bright's disease. There are instances in which specific alterations of function
correlate with pathologic involvement of a particular site of the nephron but these appear to
represent the exceptions, and in general the more advanced the disease becomes, the less …