Identification of outer membrane proteins of Mycobacterium tuberculosis
H Song, R Sandie, Y Wang, MA Andrade-Navarro… - Tuberculosis, 2008 - Elsevier
The cell wall of mycobacteria contains an unusual outer membrane of extremely low
permeability. While Escherichia coli uses more than 60 proteins to functionalize its outer
membrane, only two mycobacterial outer membrane proteins (OMPs) are known. The porin
MspA of Mycobacterium smegmatis provided the proof of principle that integral
mycobacterial OMPs share the β-barrel structure, the absence of hydrophobic α-helices and
the presence of a signal peptide with OMPs of gram-negative bacteria. These properties …
permeability. While Escherichia coli uses more than 60 proteins to functionalize its outer
membrane, only two mycobacterial outer membrane proteins (OMPs) are known. The porin
MspA of Mycobacterium smegmatis provided the proof of principle that integral
mycobacterial OMPs share the β-barrel structure, the absence of hydrophobic α-helices and
the presence of a signal peptide with OMPs of gram-negative bacteria. These properties …