[HTML][HTML] Toll-like receptor agonists promote prolonged triglyceride storage in macrophages
Y Huang, J Morales-Rosado, J Ray, TG Myers… - Journal of Biological …, 2014 - ASBMB
Macrophages in infected tissues may sense microbial molecules that significantly alter their
metabolism. In a seeming paradox, these critical host defense cells often respond by
increasing glucose catabolism while simultaneously storing fatty acids (FA) as triglycerides
(TAG) in lipid droplets. We used a load-chase strategy to study the mechanisms that promote
long term retention of TAG in murine and human macrophages. Toll-like receptor (TLR) 1/2,
TLR3, and TLR4 agonists all induced the cells to retain TAG for≥ 3 days. Prolonged TAG …
metabolism. In a seeming paradox, these critical host defense cells often respond by
increasing glucose catabolism while simultaneously storing fatty acids (FA) as triglycerides
(TAG) in lipid droplets. We used a load-chase strategy to study the mechanisms that promote
long term retention of TAG in murine and human macrophages. Toll-like receptor (TLR) 1/2,
TLR3, and TLR4 agonists all induced the cells to retain TAG for≥ 3 days. Prolonged TAG …