[HTML][HTML] Biofilms can be dispersed by focusing the immune system on a common family of bacterial nucleoid-associated proteins
SD Goodman, KP Obergfell, JA Jurcisek, LA Novotny… - Mucosal …, 2011 - Elsevier
Bacteria that cause chronic and/or recurrent diseases often rely on a biofilm lifestyle. The
foundation of the biofilm structure is the extracellular polymeric substance (EPS) that acts as
a barrier to both effectors of the immune system and antimicrobial agents. Recent work has
highlighted extracellular DNA (eDNA) as a key component common to many pathogenic
biofilms. Here, we show that the DNABII family of proteins, well known for their strong
structural influences on intracellular DNA, was also critical for the integrity of the EPS matrix …
foundation of the biofilm structure is the extracellular polymeric substance (EPS) that acts as
a barrier to both effectors of the immune system and antimicrobial agents. Recent work has
highlighted extracellular DNA (eDNA) as a key component common to many pathogenic
biofilms. Here, we show that the DNABII family of proteins, well known for their strong
structural influences on intracellular DNA, was also critical for the integrity of the EPS matrix …