[HTML][HTML] High mobility group protein 1 interacts specifically with the core domain of human TATA box-binding protein and interferes with transcription factor IIB within …
M Sutrias-Grau, ME Bianchi, J Bernués - Journal of Biological Chemistry, 1999 - ASBMB
The high mobility group (HMG) box domain has defined a family of proteins, mostly
transcription factors, that specifically interacts with DNA on the minor groove and sharply
bends it. The founding member of the family, HMG1, does not specifically recognize regular
B-DNA but is recruited to DNA by interaction with other transcription factors and TATA box-
binding protein (TBP). However, conflicting effects of HMG1 on transcription have been
reported. We show that the interaction between HMG1 and TBP is species-specific. This …
transcription factors, that specifically interacts with DNA on the minor groove and sharply
bends it. The founding member of the family, HMG1, does not specifically recognize regular
B-DNA but is recruited to DNA by interaction with other transcription factors and TATA box-
binding protein (TBP). However, conflicting effects of HMG1 on transcription have been
reported. We show that the interaction between HMG1 and TBP is species-specific. This …