[HTML][HTML] HLA-E allelic variants: correlating differential expression, peptide affinities, crystal structures, and thermal stabilities

RK Strong, MA Holmes, P Li, L Braun, N Lee… - Journal of Biological …, 2003 - ASBMB
Previous studies of HLA-E allelic polymorphism have indicated that balancing selection may
be acting to maintain two major alleles in most populations, indicating that a functional
difference may exist between the alleles. The alleles differ at only one amino acid position,
where an arginine at position 107 in HLA-E* 0101 (ER) is replaced by a glycine in HLA-E*
0103 (EG). To investigate possible functional differences, we have undertaken a study of the
physical and biochemical properties of these two proteins. By comparing expression levels …