Expression of HLA-E molecules in the placental tissue of women infected with HIV-1 and uninfected women
J Martinez, MR Santiago, G Martelli-Palomino… - Placenta, 2017 - Elsevier
Abstract Introduction Expression of HLA-E molecule in the placental extravillous trophoblast
is associated with immune system cell inhibition, resulting in immune tolerance to fetus
during pregnancy. HIV-1 can infect trophoblast cells and modify the expression of HLA-E,
which may inhibit the cytotoxic activity of the immune system. Aim The aim of this study was
to evaluate HLA-E expression in third trimester placental tissue of women infected with HIV-
1 and uninfected women. Methods We performed an immunohistochemistry assay to …
is associated with immune system cell inhibition, resulting in immune tolerance to fetus
during pregnancy. HIV-1 can infect trophoblast cells and modify the expression of HLA-E,
which may inhibit the cytotoxic activity of the immune system. Aim The aim of this study was
to evaluate HLA-E expression in third trimester placental tissue of women infected with HIV-
1 and uninfected women. Methods We performed an immunohistochemistry assay to …