The times they're a-changing: effects of circadian desynchronization on physiology and disease

DA Golombek, LP Casiraghi, PV Agostino… - Journal of physiology …, 2013 - Elsevier
Circadian rhythms are endogenous and need to be continuously entrained (synchronized)
with the environment. Entrainment includes both coupling internal oscillators to external
periodic changes as well as synchrony between the central clock and peripheral oscillators,
which have been shown to exhibit different phases and resynchronization speed. Temporal
desynchronization induces diverse physiological alterations that ultimately decrease quality
of life and induces pathological situations. Indeed, there is a considerable amount of …