Altered dentate gyrus microstructure in individuals at high familial risk for depression predicts future symptoms
MT van Dijk, J Cha, D Semanek, N Aw… - Biological Psychiatry …, 2021 - Elsevier
Background Offspring of individuals with major depressive disorder (MDD) are at increased
risk for developing MDD themselves. Altered hippocampal, and specifically dentate gyrus
(DG), structure and function may be involved in depression development. However,
hippocampal abnormalities could also be a consequence of the disease. For the first time,
we tested whether abnormal DG micro-and macrostructure were present in offspring of
individuals with MDD and whether these abnormalities predicted future symptomatology …
risk for developing MDD themselves. Altered hippocampal, and specifically dentate gyrus
(DG), structure and function may be involved in depression development. However,
hippocampal abnormalities could also be a consequence of the disease. For the first time,
we tested whether abnormal DG micro-and macrostructure were present in offspring of
individuals with MDD and whether these abnormalities predicted future symptomatology …