The tumor necrosis factor receptor superfamily (TNFRSF) and their ligands mediate
lymphoid tissue development and homeostasis in addition to key aspects of innate and
adaptive immune responses. T cells of the adaptive immune system express a number of
TNFRSF members that are used to receive signals at different instructive stages and
produce several tumor necrosis factor superfamily (TNFSF) members as effector molecules.
There is also one example of a TNFRSF member serving as a ligand for negative regulatory …