Progranulin: a conductor of receptors orchestra, a chaperone of lysosomal enzymes and a therapeutic target for multiple diseases
Y Cui, A Hettinghouse, C Liu - Cytokine & growth factor reviews, 2019 - Elsevier
Progranulin (PGRN), a widely expressed glycoprotein with pleiotropic function, has been
linked to a host of physiological processes and diverse pathological states. A series of
contemporary preclinical disease models and clinical trials have evaluated various
therapeutic strategies targeting PGRN, highlighting PGRN as a promising therapeutic target.
Herein we summarize available knowledge of PGRN targeting in various kinds of diseases,
including common neurological diseases, inflammatory autoimmune diseases, cancer …
linked to a host of physiological processes and diverse pathological states. A series of
contemporary preclinical disease models and clinical trials have evaluated various
therapeutic strategies targeting PGRN, highlighting PGRN as a promising therapeutic target.
Herein we summarize available knowledge of PGRN targeting in various kinds of diseases,
including common neurological diseases, inflammatory autoimmune diseases, cancer …