[HTML][HTML] Effects of treatment of metabolic acidosis in CKD: a systematic review and meta-analysis
SD Navaneethan, J Shao, J Buysse… - Clinical Journal of the …, 2019 - journals.lww.com
Results Fourteen clinical trials were included (n= 1394 participants). Treatment of metabolic
acidosis with oral alkali supplementation or a reduction of dietary acid intake increased
serum bicarbonate levels (14 studies, 1378 patients, mean difference 3.33 mEq/L, 95% CI,
2.37 to 4.29) and resulted in a slower decline in eGFR (13 studies, 1329 patients, mean
difference− 3.28 ml/min per 1.73 m 2, 95% CI,− 4.42 to− 2.14; moderate certainty) and a
reduction in urinary albumin excretion (very-low certainty), along with a reduction in the risk …
acidosis with oral alkali supplementation or a reduction of dietary acid intake increased
serum bicarbonate levels (14 studies, 1378 patients, mean difference 3.33 mEq/L, 95% CI,
2.37 to 4.29) and resulted in a slower decline in eGFR (13 studies, 1329 patients, mean
difference− 3.28 ml/min per 1.73 m 2, 95% CI,− 4.42 to− 2.14; moderate certainty) and a
reduction in urinary albumin excretion (very-low certainty), along with a reduction in the risk …