Fetuin-mineral complex reflects extraosseous calcification stress in CKD
T Hamano, I Matsui, S Mikami, K Tomida… - Journal of the …, 2010 - journals.lww.com
Fetuin-A is an important inhibitor of extraosseous calcification, but some of the studies that
used ELISAs did not identify a significant relationship between serum fetuin-A levels and
vascular calcification in patients with chronic kidney disease (CKD). Here, we used
centrifugation to separate a fetuin-mineral complex (FMC) composed of fetuin-A, fibrinogen,
fibronectin-1, and calcium from the serum of hemodialysis patients. In addition, we analyzed
serum fetuin-A levels of 73 patients with diabetes and CKD (predialysis) after centrifugation …
used ELISAs did not identify a significant relationship between serum fetuin-A levels and
vascular calcification in patients with chronic kidney disease (CKD). Here, we used
centrifugation to separate a fetuin-mineral complex (FMC) composed of fetuin-A, fibrinogen,
fibronectin-1, and calcium from the serum of hemodialysis patients. In addition, we analyzed
serum fetuin-A levels of 73 patients with diabetes and CKD (predialysis) after centrifugation …