[HTML][HTML] The nuclear receptor Rev-erbα regulates adipose tissue-specific FGF21 signaling
FGF21 is an atypical member of the FGF family that functions as a hormone to regulate
carbohydrate and lipid metabolism. Here we demonstrate that the actions of FGF21 in
mouse adipose tissue, but not in liver, are modulated by the nuclear receptor Rev-erbα, a
potent transcriptional repressor. Interrogation of genes induced in the absence of Rev-erbα
for Rev-erbα-binding sites identified βKlotho, an essential coreceptor for FGF21, as a direct
target gene of Rev-erbα in white adipose tissue but not liver. Rev-erbα ablation led to the …
carbohydrate and lipid metabolism. Here we demonstrate that the actions of FGF21 in
mouse adipose tissue, but not in liver, are modulated by the nuclear receptor Rev-erbα, a
potent transcriptional repressor. Interrogation of genes induced in the absence of Rev-erbα
for Rev-erbα-binding sites identified βKlotho, an essential coreceptor for FGF21, as a direct
target gene of Rev-erbα in white adipose tissue but not liver. Rev-erbα ablation led to the …