[HTML][HTML] Identification of Rev-erbα as a physiological repressor of apoC-III gene transcription1
E Raspé, H Duez, A Mansén, C Fontaine, C Fiévet… - Journal of lipid …, 2002 - ASBMB
Elevated serum levels of triglyceride-rich remnant lipoproteins (TRL) are a major risk factor
predisposing a subject to atherosclerosis. Apolipoprotein C-III (apoC-III) is a major
constituent of TRL that impedes triglyceride hydrolysis and remnant clearance and, as such,
may exert pro-atherogenic activities. In the present study, transient cotransfection
experiments in rat hepatocytes in primary culture and rabbit kidney RK13 cells demonstrated
that overexpression of Rev-erbα specifically decreases basal and HNF-4 stimulated human …
predisposing a subject to atherosclerosis. Apolipoprotein C-III (apoC-III) is a major
constituent of TRL that impedes triglyceride hydrolysis and remnant clearance and, as such,
may exert pro-atherogenic activities. In the present study, transient cotransfection
experiments in rat hepatocytes in primary culture and rabbit kidney RK13 cells demonstrated
that overexpression of Rev-erbα specifically decreases basal and HNF-4 stimulated human …