The stress-inducible HspB8-Bag3 complex induces the eIF2α kinase pathway: implications for protein quality control and viral factory degradation?
S Carra - Autophagy, 2009 - Taylor & Francis
S Carra
Autophagy, 2009•Taylor & FrancisThe recently discovered HspB8-Bag3 complex participates in protein quality control through
a mechanism that requires the activation of the eIF2α signaling pathway and that leads to
protein synthesis inhibition and autophagy stimulation. Both processes help to protect the
cells against the accumulation of aggregate-prone proteins, which may be relevant in many
protein conformational neurodegenerative disorders. Besides, this activity of HspB8-Bag3
may have important implications during viral infection.
a mechanism that requires the activation of the eIF2α signaling pathway and that leads to
protein synthesis inhibition and autophagy stimulation. Both processes help to protect the
cells against the accumulation of aggregate-prone proteins, which may be relevant in many
protein conformational neurodegenerative disorders. Besides, this activity of HspB8-Bag3
may have important implications during viral infection.
The recently discovered HspB8-Bag3 complex participates in protein quality control through a mechanism that requires the activation of the eIF2α signaling pathway and that leads to protein synthesis inhibition and autophagy stimulation. Both processes help to protect the cells against the accumulation of aggregate-prone proteins, which may be relevant in many protein conformational neurodegenerative disorders. Besides, this activity of HspB8-Bag3 may have important implications during viral infection.
Taylor & Francis Online