[HTML][HTML] An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators

S Takayama, Z Xie, JC Reed - Journal of Biological Chemistry, 1999 - ASBMB
Heat Shock Protein 70 kDa (Hsp70) family molecular chaperones play critical roles in
protein folding and trafficking in all eukaryotic cells. The mechanisms by which Hsp70 family
chaperones are regulated, however, are only partly understood. BAG-1 binds the ATPase
domains of Hsp70 and Hsc70, modulating their chaperone activity and functioning as a
competitive antagonist of the co-chaperone Hip. We describe the identification of a family of
BAG-1-related proteins from humans (BAG-2, BAG-3, BAG-4, BAG-5), the invertebrate …