Additional Drug Resistance in Mycobacterium tuberculosis Isolates From Resected Cavities Among Patients With Multidrug-Resistant or Extensively Drug-Resistant …

RR Kempker, AS Rabin, K Nikolaishvili… - Clinical Infectious …, 2012 - academic.oup.com
RR Kempker, AS Rabin, K Nikolaishvili, I Kalandadze, S Gogishvili, HM Blumberg
Clinical Infectious Diseases, 2012academic.oup.com
The pathogenesis of increasing drug resistance among patients with multidrug-resistant or
extensively drug-resistant tuberculosis undergoing treatment is poorly understood.
Increasing drug resistance found among Mycobacterium tuberculosis recovered from
cavitary isolates compared with paired sputum isolates suggests pulmonary cavities may
play a role in the development of worsening tuberculosis drug resistance.
Abstract
The pathogenesis of increasing drug resistance among patients with multidrug-resistant or extensively drug-resistant tuberculosis undergoing treatment is poorly understood. Increasing drug resistance found among Mycobacterium tuberculosis recovered from cavitary isolates compared with paired sputum isolates suggests pulmonary cavities may play a role in the development of worsening tuberculosis drug resistance.
Oxford University Press