The morphological and molecular mechanisms of epithelial/endothelial-to-mesenchymal transition and its involvement in atherosclerosis
M Wesseling, TR Sakkers, SCA De Jager… - Vascular …, 2018 - Elsevier
Cell transdifferentiation occurs during cardiovascular development or remodeling either as a
pathologic feature in the progression of disease or as a response to injury. Endothelial-to-
Mesenchymal Transition (EndMT) is a process that is classified as a specialized form of
Epithelial-to-Mesenchymal Transition (EMT), in which epithelial cells lose their epithelial
characteristics and gain a mesenchymal phenotype. During transdifferentiation, cells lose
both cell-cell contacts and their attachment to the basement membrane. Subsequently, the …
pathologic feature in the progression of disease or as a response to injury. Endothelial-to-
Mesenchymal Transition (EndMT) is a process that is classified as a specialized form of
Epithelial-to-Mesenchymal Transition (EMT), in which epithelial cells lose their epithelial
characteristics and gain a mesenchymal phenotype. During transdifferentiation, cells lose
both cell-cell contacts and their attachment to the basement membrane. Subsequently, the …