[HTML][HTML] Chronic hexosamine flux stimulates fatty acid oxidation by activating AMP-activated protein kinase in adipocytes
B Luo, GJ Parker, RC Cooksey, Y Soesanto… - Journal of biological …, 2007 - ASBMB
The hexosamine biosynthesis pathway (HBP) serves as a nutrient sensor and has been
implicated in the development of type 2 diabetes. We previously demonstrated that fatty acid
oxidation was enhanced in transgenic mouse adipocytes, wherein the rate-limiting enzyme
of the HBP, glutamine: fructose-6-phosphate amidotransferase (GFA), was overexpressed.
To explore the molecular mechanism of the HBP-induced fatty acid oxidation in adipocytes,
we studied AMP-activated protein kinase (AMPK), an energy sensor that stimulates fatty acid …
implicated in the development of type 2 diabetes. We previously demonstrated that fatty acid
oxidation was enhanced in transgenic mouse adipocytes, wherein the rate-limiting enzyme
of the HBP, glutamine: fructose-6-phosphate amidotransferase (GFA), was overexpressed.
To explore the molecular mechanism of the HBP-induced fatty acid oxidation in adipocytes,
we studied AMP-activated protein kinase (AMPK), an energy sensor that stimulates fatty acid …