'Yin–Yang'functions of transforming growth factor‐β and T regulatory cells in immune regulation
YY Wan, RA Flavell - Immunological reviews, 2007 - Wiley Online Library
Immunological reviews, 2007•Wiley Online Library
Transforming growth factor‐β (TGF‐β) and forkhead box p3‐expressing T‐regulatory (Treg)
cells are critical in maintaining self‐tolerance and immune homeostasis. The immune
suppressive functions of TGF‐β and Treg cells are widely acknowledged and extensively
studied. Nonetheless, recent studies revealed the positive roles of TGF‐β and Treg cells in
shaping the immune system and the inflammatory responses. This review discusses our and
other's efforts in understanding the negative (Yin) as well as the positive (Yang) roles for …
cells are critical in maintaining self‐tolerance and immune homeostasis. The immune
suppressive functions of TGF‐β and Treg cells are widely acknowledged and extensively
studied. Nonetheless, recent studies revealed the positive roles of TGF‐β and Treg cells in
shaping the immune system and the inflammatory responses. This review discusses our and
other's efforts in understanding the negative (Yin) as well as the positive (Yang) roles for …
Summary
Transforming growth factor‐β (TGF‐β) and forkhead box p3‐expressing T‐regulatory (Treg) cells are critical in maintaining self‐tolerance and immune homeostasis. The immune suppressive functions of TGF‐β and Treg cells are widely acknowledged and extensively studied. Nonetheless, recent studies revealed the positive roles of TGF‐β and Treg cells in shaping the immune system and the inflammatory responses. This review discusses our and other's efforts in understanding the negative (Yin) as well as the positive (Yang) roles for TGF‐β and Treg cells in immune regulation.
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