Insights from invasive cardiopulmonary exercise testing of patients with myalgic encephalomyelitis/chronic fatigue syndrome
Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) affects tens of
millions worldwide; the causes of exertional intolerance are poorly understood. The ME/CFS
label overlaps with postural orthostatic tachycardia (POTS) and fibromyalgia, and objective
evidence of small fiber neuropathy (SFN) is reported in approximately 50% áof POTS and
fibromyalgia patients. Research Question Can invasive cardiopulmonary exercise testing
(iCPET) and PGP9. 5-immunolabeled lower-leg skin biopsies inform the pathophysiology of …
millions worldwide; the causes of exertional intolerance are poorly understood. The ME/CFS
label overlaps with postural orthostatic tachycardia (POTS) and fibromyalgia, and objective
evidence of small fiber neuropathy (SFN) is reported in approximately 50% áof POTS and
fibromyalgia patients. Research Question Can invasive cardiopulmonary exercise testing
(iCPET) and PGP9. 5-immunolabeled lower-leg skin biopsies inform the pathophysiology of …