Use of heparin in the treatment of protein-losing enteropathy after Fontan operation for complex congenital heart disease
AM Kelly, RH Feldt, DJ Driscoll, GK Danielson - Mayo Clinic Proceedings, 1998 - Elsevier
AM Kelly, RH Feldt, DJ Driscoll, GK Danielson
Mayo Clinic Proceedings, 1998•ElsevierProtein-losing enteropathy (PLE) is a serious complication of the Fontan operation and is
associated with pronounced mortality. Medical management of PLE has been only partially
successful. A recent report noted dramatic improvement in patients with PLE within 3 weeks
of subcutaneous administration of heparin. We report a case of reversal of PLE with
resolution of clinical symptoms and normalization of serum albumin, total protein, and fecal α
1,-antitrypsin values after several months of heparin treatment. Our findings substantiate …
associated with pronounced mortality. Medical management of PLE has been only partially
successful. A recent report noted dramatic improvement in patients with PLE within 3 weeks
of subcutaneous administration of heparin. We report a case of reversal of PLE with
resolution of clinical symptoms and normalization of serum albumin, total protein, and fecal α
1,-antitrypsin values after several months of heparin treatment. Our findings substantiate …
Protein-losing enteropathy (PLE) is a serious complication of the Fontan operation and is associated with pronounced mortality. Medical management of PLE has been only partially successful. A recent report noted dramatic improvement in patients with PLE within 3 weeks of subcutaneous administration of heparin. We report a case of reversal of PLE with resolution of clinical symptoms and normalization of serum albumin, total protein, and fecal α1,-antitrypsin values after several months of heparin treatment. Our findings substantiate those recently reported but suggest that reversal of PLE may necessitate more than a few weeks of heparin therapy.
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