[HTML][HTML] Interplay between FOXO, TOR, and Akt
N Hay - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2011 - Elsevier
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2011•Elsevier
FOXO transcription factors have emerged as rheostats that coordinate the activities of Akt
and targets of rapamycin complexes (TORCs). This review summarizes the regulatory
circuits mediated by the activation of FOXO, which in turn modulate Akt and TORCs
activities. The biological significance of these regulatory circuits is discussed in this article.
This article is part of a Special Issue entitled: P13K-AKT-FoxO axis in cancer and aging.
and targets of rapamycin complexes (TORCs). This review summarizes the regulatory
circuits mediated by the activation of FOXO, which in turn modulate Akt and TORCs
activities. The biological significance of these regulatory circuits is discussed in this article.
This article is part of a Special Issue entitled: P13K-AKT-FoxO axis in cancer and aging.
FOXO transcription factors have emerged as rheostats that coordinate the activities of Akt and targets of rapamycin complexes (TORCs). This review summarizes the regulatory circuits mediated by the activation of FOXO, which in turn modulate Akt and TORCs activities. The biological significance of these regulatory circuits is discussed in this article. This article is part of a Special Issue entitled: P13K-AKT-FoxO axis in cancer and aging.
Elsevier