We previously demonstrated that protein kinase C-δ (PKCδ) is critical for immunity against
Listeria monocytogenes, Leishmania major, and Candida albicans infection in mice.
However, the functional relevance of PKCδ during Mycobacterium tuberculosis (Mtb)
infection is unknown. PKCδ was significantly upregulated in whole blood of patients with
active tuberculosis (TB) disease. Lung proteomics further revealed that PKCδ was highly
abundant in the necrotic and cavitory regions of TB granulomas in multidrug-resistant …